Gather all ingredients and set up your workspace with a mixing bowl and cooking appliance.

In the bowl, mix the ground turkey, garlic powder, onion powder, Worcestershire sauce, salt, and pepper until just combined.

Divide the mixture into four equal portions and shape them into patties about one inch thick.

Preheat your grill to medium-high heat or heat a skillet over medium heat with a bit of oil.

Cook the patties for about 5 minutes per side or until they reach an internal temperature of 165°F (75°C).

Assemble burgers on buns with lettuce and tomatoes or any desired toppings.